Aging, Osteocytes, and Mechanotransduction
نویسندگان
چکیده
منابع مشابه
Aging, Osteocytes, and Mechanotransduction
PURPOSE OF REVIEW The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging. RECENT FINDINGS Severa...
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The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication. In this article, we report successfully isolating primary cultures of osteocytes from chick calvaria, and, using anti-connexin 43 immunocytochemistry, demonstrate gap junction distribution to...
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ژورنال
عنوان ژورنال: Current Osteoporosis Reports
سال: 2017
ISSN: 1544-1873,1544-2241
DOI: 10.1007/s11914-017-0402-z